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Welcome to the Johne's Disease Integrated Program (JDIP) website, a public resource for researchers and others interested in the diagnosis, treatment, prevention and control of Johne's Disease. The site includes both areas open to the public and secure areas available to researchers participating in the JDIP projects. Visitors are welcome to view any of the public sections on this site. If you are a JDIP Investigator and don't already have a login, please contact the Principal Investigator,
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for login information that will allow you access to the secure areas. . The site will evolve as the project progresses and content will be added as it becomes available. We invite you to check back often.
JDIP – Year 6 Request For Applications
Thank you to all of those who applied for the JDIP Year 6 RFA. The JDIP received and reviewed a total of 23 proposals in response to the Year 6 Request for Applications (RFA) with a total funding request exceeding $2.1 million. For the current funding cycle a total of $700,000 were available for support of JDIP programs and operations. Please visit the "Funding Opportunities" link for the results.
May 2010 JDIP Newsletter
Check out the latest information on JDIP. The May 2010 issue of "JDIP News" is now available. It includes articles about the JDIP year 6 funding results, the JDIP Annual Meeting at the JAM, updates with the APHIS-JDIP vaccine project and the diagnostics test standardization project, and overviews of other JDIP activities.
Core 1 Update
Core 1 is pleased to report that they have completed the software development of two user-friendly programs that help 1) in understanding the dynamics of Johne’s Disease with test-and-cull intervention in a dairy herd, and 2) for estimation of the Receiver Operating Characteristic (ROC) curve for the ELISA test. Please visit the Core 1 link under the Core Resources tab for further information.
Project 2: Diagnostics Project Update
Please visit the "Project 2: Diagnostics Project Update" link for further information.
The APHIS-JDIP Vaccine Project
After much discussion, coordination, and paper work, we are now ready to initiate the USDA-APHIS sponsored vaccine testing program, and will be accepting submissions for participation in the program.
Submission guidelines and forms for live MAP vaccine candidates (
PDF or
Word
) are
also available. Please forward to any investigators whom you feel may have an interest since this is an excellent opportunity to evaluate your candidate vaccines in a direct comparison with other candidates submitted by your peers.
For those who are unfamiliar with the program, there is interest among many veterinarians and producers alike in the application of vaccination as a tool in Johne’s programs; however, there is only one vaccine available at the present time. That vaccine has limitations and is not approved for use in all states. JDIP scientists are working closely with USDA-APHIS-VS in an effort to identify viable vaccine candidates and evaluate those with the greatest potential for commercial development. The project is in the initial stages of a three step process.
Phase I – Potential candidates are currently being solicited. This includes both modified live organisms and subunits. In vitro screening in two laboratories will identify the “Best Candidates.”
Phase II - These “Best Candidates” will next be evaluated through the use of a mouse model. It is anticipated that two laboratories will conduct the infection/protection studies in the mouse.
Phase III – The “Best Candidates” identified through the mouse studies will then be evaluated using a “Goat model.” This will provide data similar to that from cattle, but the data are available in a much shorter time frame and at a lower cost.
New Johne's Strategic Plan
A new "Strategic Plan" for addressing Johne's Disease was adopted at the 2008 US Animal Health Association Annual Meeting. The plan outlines new roles for industry and academia, as well as state and federal agencies, as we work together to address this important disease.New Johne's Strategic Plan
Please contact Ken Olson
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with any questions of comments on the plan.
National Dairy Producer Johne’s Survey
A National Dairy Producer Johne's survey, funded by the Johne’s Disease Integrated Program (JDIP) and led by Penn State University has recently been completed. The survey, which was mailed to approximately 15% of the dairy producers in each state, sought to identify barriers to and incentives for participation in the Voluntary Bovine Johne's Disease Control Program. Over 2,000 surveys were returned. Results are being analyzed in detail, but several preliminary results are of special interest.
► Approximately 50% of those responding have had Johne’s disease diagnosed or have seen clinical signs of the disease in their herd
► Approximately 1/3 did not know if their state had a Johne’s program
► Concern over Johne’s was the primary reason identified for participating in the program. Financial incentives, such as reduced testing cost and Risk Assessments, were positive factors.
► Over 80% listed Farm magazines and Veterinarians as primary Johne’s Information sources. Veterinarians, farm magazines and extension were the most reliable sources of information
Additional details will be available at http://vetextension.psu.edu and http://www.jdip.org/ and through upcoming publications.
Contact
Should you need any assistance regarding JDIP, please feel free to contact the JDIP Project Assistant, Tiffany Cunningham, via email at
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or by phone at (814) 867-0261.
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